Product Name :
HDAC-IN-4
Description:
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity.
CAS:
1252003-13-6
Molecular Weight:
335.40
Formula:
C20H21N3O2
Chemical Name:
N-hydroxy-4-(2-methyl-1H, 2H, 3H, 4H, 9H-pyrido[3, 4-b]indol-9-ylmethyl)benzamide
Smiles :
CN1CC2=C(CC1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
InChiKey:
JVELXRPQMVXDDP-UHFFFAOYSA-N
InChi :
InChI=1S/C20H21N3O2/c1-22-11-10-17-16-4-2-3-5-18(16)23(19(17)13-22)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.7-Amino-4-methylcoumarin Technical Information
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Betamethasone dipropionate Technical Information
Additional information:
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.PMID:33222632 2 and 6.8 in BRET assay, respectively. Antitumoral activity.|Product information|CAS Number: 1252003-13-6|Molecular Weight: 335.40|Formula: C20H21N3O2|Chemical Name: N-hydroxy-4-(2-methyl-1H, 2H, 3H, 4H, 9H-pyrido[3, 4-b]indol-9-ylmethyl)benzamide|Smiles: CN1CC2=C(CC1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO|InChiKey: JVELXRPQMVXDDP-UHFFFAOYSA-N|InChi: InChI=1S/C20H21N3O2/c1-22-11-10-17-16-4-2-3-5-18(16)23(19(17)13-22)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HDAC-IN-4 inhibits HDAC1, HDAC2, HDAC3, HDAC8 and HDAC10 with pIC50s of 5.5, 4.6, 5.4, 5.4, 6.7 in FRET assay, respectively. HDAC-IN-4 is more potent against HDAC6 than Tubastatin A, suggests that HDAC-IN-4 may be a better HDAC6 probe than Tubastatin A.|Products are for research use only. Not for human use.|
