Product Name :
CID 5951923
Description:
CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro.
CAS:
749872-43-3
Molecular Weight:
382.39
Formula:
C16H18N2O7S
Chemical Name:
[(1, 1-dioxo-1-thiolan-3-yl)(methyl)carbamoyl]methyl (2E)-3-(3-nitrophenyl)prop-2-enoate
Smiles :
CN(C1CS(=O)(=O)CC1)C(=O)COC(=O)/C=C/C1=CC(=CC=C1)[N+]([O-])=O
InChiKey:
URVRJYLSUVXWBC-AATRIKPKSA-N
InChi :
InChI=1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{MK-1084} web|{MK-1084} Ras|{MK-1084} Activator|{MK-1084} Protocol|{MK-1084} Purity|{MK-1084} custom synthesis}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Fasudil} MedChemExpress|{Fasudil} Autophagy|{Fasudil} Epigenetics|{Fasudil} Technical Information|{Fasudil} In Vivo|{Fasudil} custom synthesis}
Additional information:
CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM.PMID:32809631 CID 5951923 can inhibit proliferation of cancer cells in vitro.|Product information|CAS Number: 749872-43-3|Molecular Weight: 382.39|Formula: C16H18N2O7S|Chemical Name: [(1, 1-dioxo-1-thiolan-3-yl)(methyl)carbamoyl]methyl (2E)-3-(3-nitrophenyl)prop-2-enoate|Smiles: CN(C1CS(=O)(=O)CC1)C(=O)COC(=O)/C=C/C1=CC(=CC=C1)[N+]([O-])=O|InChiKey: URVRJYLSUVXWBC-AATRIKPKSA-N|InChi: InChI=1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner. CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1. CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells.|References:|Bialkowska AB, et, al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther. 2011 Nov; 10(11): 2043-51.Products are for research use only. Not for human use.|
