Product Name :
Metoprine
Description:
Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Metoprine is an antifolate and antitumor agent.
CAS:
7761-45-7
Molecular Weight:
269.13
Formula:
C11H10Cl2N4
Chemical Name:
5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine
Smiles :
CC1=NC(N)=NC(N)=C1C1=CC(Cl)=C(Cl)C=C1
InChiKey:
VQJHOPSWBGJHQS-UHFFFAOYSA-N
InChi :
InChI=1S/C11H10Cl2N4/c1-5-9(10(14)17-11(15)16-5)6-2-3-7(12)8(13)4-6/h2-4H,1H3,(H4,14,15,16,17)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor.{{Cadonilimab} web|{Cadonilimab} CTLA-4|{Cadonilimab} Protocol|{Cadonilimab} In stock|{Cadonilimab} custom synthesis|{Cadonilimab} Autophagy} Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.{{Sphingosine-1-phosphate} MedChemExpress|{Sphingosine-1-phosphate} GPCR/G Protein|{Sphingosine-1-phosphate} Protocol|{Sphingosine-1-phosphate} Description|{Sphingosine-1-phosphate} custom synthesis|{Sphingosine-1-phosphate} Cancer} Metoprine is an antifolate and antitumor agent.|Product information|CAS Number: 7761-45-7|Molecular Weight: 269.13|Formula: C11H10Cl2N4|Chemical Name: 5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine|Smiles: CC1=NC(N)=NC(N)=C1C1=CC(Cl)=C(Cl)C=C1|InChiKey: VQJHOPSWBGJHQS-UHFFFAOYSA-N|InChi: InChI=1S/C11H10Cl2N4/c1-5-9(10(14)17-11(15)16-5)6-2-3-7(12)8(13)4-6/h2-4H,1H3,(H4,14,15,16,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 20.PMID:32786035 83 mg/mL (77.40 mM; ultrasonic and warming and heat to 60°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner. Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption.|Products are for research use only. Not for human use.|
