Product Name :
AG 555
Description:
AG 555 (Tyrphostin AG 555), a potent antiretroviral drug, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation.
CAS:
133550-34-2
Molecular Weight:
322.36
Formula:
C19H18N2O3
Chemical Name:
(2E)-2-cyano-3-(3, 4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide
Smiles :
N#C/C(=C\C1=CC(O)=C(O)C=C1)/C(=O)NCCCC1C=CC=CC=1
InChiKey:
GSQOBTOAOGXIFL-LFIBNONCSA-N
InChi :
InChI=1S/C19H18N2O3/c20-13-16(11-15-8-9-17(22)18(23)12-15)19(24)21-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,22-23H,4,7,10H2,(H,21,24)/b16-11+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AG 555 (Tyrphostin AG 555), a potent antiretroviral drug, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation.|Product information|CAS Number: 133550-34-2|Molecular Weight: 322.36|Formula: C19H18N2O3|Synonym:|Tyrphostin AG 555|Chemical Name: (2E)-2-cyano-3-(3, 4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide|Smiles: N#C/C(=C\C1=CC(O)=C(O)C=C1)/C(=O)NCCCC1C=CC=CC=1|InChiKey: GSQOBTOAOGXIFL-LFIBNONCSA-N|InChi: InChI=1S/C19H18N2O3/c20-13-16(11-15-8-9-17(22)18(23)12-15)19(24)21-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,22-23H,4,7,10H2,(H,21,24)/b16-11+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (310.21 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{MTEP} MedChemExpress|{MTEP} mGluR|{MTEP} NF-κB|{MTEP} Protocol|{MTEP} In stock|{MTEP} supplier} |Shelf Life: ≥360 days if stored properly.{{Melittin} web|{Melittin} Metabolic Enzyme/Protease|{Melittin} Epigenetics|{Melittin} Technical Information|{Melittin} Data Sheet|{Melittin} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33232022 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle. Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells. Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence.|References:|Seri E Aflalo, et al. Tyrphostin AG-555 inhibits early and late stages of Moloney murine leukemia virus replication cycle. International Journal of Oncology. 1997.Nir Osherov, et al. Tyrphostin AG494 blocks Cdk2 activation Nir Osherov. FEBS Letters 410 (1997) 187-190Sabine Baars, et al. Tyrphostin AG 555 Inhibits Bovine Papillomavirus Transcription by Changing the Ratio between E2 Transactivator/Repressor Function. Vol. 278, No. 39, Issue of September 26, pp. 37306–37313, 2003.Products are for research use only. Not for human use.|
