Product Name :
PACMA 31
Description:
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues.
CAS:
1401089-31-3
Molecular Weight:
430.47
Formula:
C21H22N2O6S
Chemical Name:
ethyl 2-{2-[N-(2,4-dimethoxyphenyl)prop-2-ynamido]-2-(thiophen-2-yl)acetamido}acetate
Smiles :
CCOC(=O)CNC(=O)C(C1=CC=CS1)N(C1=CC=C(C=C1OC)OC)C(=O)C#C
InChiKey:
AHOOZADJPNUFOQ-UHFFFAOYSA-N
InChi :
InChI=1S/C21H22N2O6S/c1-5-18(24)23(15-10-9-14(27-3)12-16(15)28-4)20(17-8-7-11-30-17)21(26)22-13-19(25)29-6-2/h1,7-12,20H,6,13H2,2-4H3,(H,22,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Calcipotriol} site|{Calcipotriol} VD/VDR|{Calcipotriol} Technical Information|{Calcipotriol} Description|{Calcipotriol} manufacturer|{Calcipotriol} Cancer}
Shelf Life:
≥12 months if stored properly.{{MTEP} MedChemExpress|{MTEP} mGluR|{MTEP} Activator|{MTEP} Biological Activity|{MTEP} In stock|{MTEP} supplier}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32956151
Additional information:
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues.|Product information|CAS Number: 1401089-31-3|Molecular Weight: 430.47|Formula: C21H22N2O6S|Chemical Name: ethyl 2-{2-[N-(2,4-dimethoxyphenyl)prop-2-ynamido]-2-(thiophen-2-yl)acetamido}acetate|Smiles: CCOC(=O)CNC(=O)C(C1=CC=CS1)N(C1=CC=C(C=C1OC)OC)C(=O)C#C|InChiKey: AHOOZADJPNUFOQ-UHFFFAOYSA-N|InChi: InChI=1S/C21H22N2O6S/c1-5-18(24)23(15-10-9-14(27-3)12-16(15)28-4)20(17-8-7-11-30-17)21(26)22-13-19(25)29-6-2/h1,7-12,20H,6,13H2,2-4H3,(H,22,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (232.30 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PACMA 31 (0-10 μM; 24 hours) significantly inhibits colony formation in OVCAR-8 cells in a dose-dependent manner.|In Vivo:|PACMA 31 (20-200 mg/kg; i.p.; daily for 62 days) suppresses tumor growth in human ovarian cancer mouse xenografts .|Products are for research use only. Not for human use.|
