Product Name :
Coronaridine
Description:
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression.
CAS:
467-77-6
Molecular Weight:
338.44
Formula:
C21H26N2O2
Chemical Name:
methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapentacyclo[13.3.1.0²,¹⁰.0⁴,⁹.0¹³,¹⁸]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
Smiles :
CC[C@H]1C[C@H]2CN3CCC4C5=CC=CC=C5NC=4[C@](C2)([C@@H]31)C(=O)OC
InChiKey:
NVVDQMVGALBDGE-PZXGUROGSA-N
InChi :
InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14+,19+,21-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression.|Product information|CAS Number: 467-77-6|Molecular Weight: 338.44|Formula: C21H26N2O2|Chemical Name: methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapentacyclo[13.3.1.0²,¹⁰.0⁴,⁹.0¹³,¹⁸]nonadeca-2(10),4,6,8-tetraene-1-carboxylate|Smiles: CC[C@H]1C[C@H]2CN3CCC4C5=CC=CC=C5NC=4[C@](C2)([C@@H]31)C(=O)OC|InChiKey: NVVDQMVGALBDGE-PZXGUROGSA-N|InChi: InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14+,19+,21-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Carotegrast} MedChemExpress|{Carotegrast} Integrin|{Carotegrast} TGF-beta/Smad|{Carotegrast} Technical Information|{Carotegrast} In Vitro|{Carotegrast} supplier} |Shelf Life: ≥12 months if stored properly.{{Fucoxanthin} web|{Fucoxanthin} Cell Cycle/DNA Damage|{Fucoxanthin} Biological Activity|{Fucoxanthin} In Vivo|{Fucoxanthin} custom synthesis|{Fucoxanthin} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23907521 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively. Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β–catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged. In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner. At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude and rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 and hα2β2γ2). The PAM activity of Catharanthine’s are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM).|Products are for research use only. Not for human use.|
