Product Name :
TRIM24-C34, BRPF1B/TRIM24 Dual Inhibitor
Description:
TRIM24-C34 is a potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor. TRIM24-C34 binds to bromodomain BRPF1B with a Kd of 137 nM, and the transcriptional regulator TRIM24 (also an E3 ubiquitin ligase) with a Kd of 222 nM. It has very good selectivity against other 45 bromodomains. Cellular activity of TRIM24-C34 was demonstrated using FRAP assays as well as cell viability data. It showed no significant cytotoxicity in the cell lines tested.
CAS:
1242907-48-7
Molecular Weight:
499.54
Formula:
C24H25N3O7S
Chemical Name:
3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide
Smiles :
COC1C=CC(=CC=1)OC1C=C2C(=CC=1NS(=O)(=O)C1=CC(OC)=C(C=C1)OC)N(C)C(=O)N2C
InChiKey:
KNVIUMWNYXDULF-UHFFFAOYSA-N
InChi :
InChI=1S/C24H25N3O7S/c1-26-19-13-18(25-35(29,30)17-10-11-21(32-4)23(12-17)33-5)22(14-20(19)27(2)24(26)28)34-16-8-6-15(31-3)7-9-16/h6-14,25H,1-5H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Favipiravir} medchemexpress|{Favipiravir} Bacterial|{Favipiravir} Protocol|{Favipiravir} In Vivo|{Favipiravir} custom synthesis|{Favipiravir} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TRIM24-C34 is a potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor. TRIM24-C34 binds to bromodomain BRPF1B with a Kd of 137 nM, and the transcriptional regulator TRIM24 (also an E3 ubiquitin ligase) with a Kd of 222 nM. It has very good selectivity against other 45 bromodomains. Cellular activity of TRIM24-C34 was demonstrated using FRAP assays as well as cell viability data. It showed no significant cytotoxicity in the cell lines tested.|Product information|CAS Number: 1242907-48-7|Molecular Weight: 499.54|Formula: C24H25N3O7S|Chemical Name: 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide|Smiles: COC1C=CC(=CC=1)OC1C=C2C(=CC=1NS(=O)(=O)C1=CC(OC)=C(C=C1)OC)N(C)C(=O)N2C|InChiKey: KNVIUMWNYXDULF-UHFFFAOYSA-N|InChi: InChI=1S/C24H25N3O7S/c1-26-19-13-18(25-35(29,30)17-10-11-21(32-4)23(12-17)33-5)22(14-20(19)27(2)24(26)28)34-16-8-6-15(31-3)7-9-16/h6-14,25H,1-5H3|Technical Data|Appearance: Solid Power.{{Loratadine} site|{Loratadine} Anti-infection|{Loratadine} Purity & Documentation|{Loratadine} In Vitro|{Loratadine} manufacturer|{Loratadine} Cancer} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 20 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23618405 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|TRIM24-C34 was used at 10 µM final concentration in various in vitro assays.|References:|Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. (2015) J Med Chem. In press.Products are for research use only. Not for human use.|Documents||
