Product Name :
MLT-747
Description:
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM.
CAS:
2097853-86-4
Molecular Weight:
478.33
Formula:
C20H21Cl2N7O3
Chemical Name:
1-[5-chloro-6-(pyrrolidine-1-carbonyl)pyridin-3-yl]-3-{2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl}urea
Smiles :
CO[C@@H](C)C1=C(C=NC2=CC(Cl)=NN21)NC(=O)NC1=CN=C(C(Cl)=C1)C(=O)N1CCCC1
InChiKey:
OJTGJRAKRGEDPI-NSHDSACASA-N
InChi :
InChI=1S/C20H21Cl2N7O3/c1-11(32-2)18-14(10-23-16-8-15(22)27-29(16)18)26-20(31)25-12-7-13(21)17(24-9-12)19(30)28-5-3-4-6-28/h7-11H,3-6H2,1-2H3,(H2,25,26,31)/t11-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Caplacizumab} web|{Caplacizumab} Protocol|{Caplacizumab} In Vivo|{Caplacizumab} manufacturer|{Caplacizumab} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{1,2-Distearoyl-sn-glycero-3-phosphorylcholine} site|{1,2-Distearoyl-sn-glycero-3-phosphorylcholine} Liposome|{1,2-Distearoyl-sn-glycero-3-phosphorylcholine} Biological Activity|{1,2-Distearoyl-sn-glycero-3-phosphorylcholine} Formula|{1,2-Distearoyl-sn-glycero-3-phosphorylcholine} custom synthesis|{1,2-Distearoyl-sn-glycero-3-phosphorylcholine} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23927631
Additional information:
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM.|Product information|CAS Number: 2097853-86-4|Molecular Weight: 478.33|Formula: C20H21Cl2N7O3|Chemical Name: 1-[5-chloro-6-(pyrrolidine-1-carbonyl)pyridin-3-yl]-3-{2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl}urea|Smiles: CO[C@@H](C)C1=C(C=NC2=CC(Cl)=NN21)NC(=O)NC1=CN=C(C(Cl)=C1)C(=O)N1CCCC1|InChiKey: OJTGJRAKRGEDPI-NSHDSACASA-N|InChi: InChI=1S/C20H21Cl2N7O3/c1-11(32-2)18-14(10-23-16-8-15(22)27-29(16)18)26-20(31)25-12-7-13(21)17(24-9-12)19(30)28-5-3-4-6-28/h7-11H,3-6H2,1-2H3,(H2,25,26,31)/t11-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM.|Products are for research use only. Not for human use.|
